Synthesis of N-acyl-4-methyl-7(8)nitro-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones and their spectral properties

Authors

  • Б. А. Пуоджюнайте M. V. Lomonosov Moscow State University, Moscow 119899
  • P. А. Янчене M. V. Lomonosov Moscow State University, Moscow 119899
  • П. Б. Тepeнтьев M. V. Lomonosov Moscow State University, Moscow 119899
  • З. А. Стумбрявичуте M. V. Lomonosov Moscow State University, Moscow 119899
  • Г. А. Булахов M. V. Lomonosov Moscow State University, Moscow 119899

Abstract

The conditions were studied o f mono- and diacylation of 7(8)-nitro-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones. It was found that under mild conditions (lower temperatures, weak acylating agents), the 7-nitro isomers are acylated only at the 5-position; increase in the temperature or treatment with an active acylating agent gives the 1,5-diacyl derivatives. Under mild conditions the 8-nitro isomer is not acylated, while under more rigorous conditions a mixture of mono- and diacylated products is formed.

How to Cite
Puodzhyunaite, B. A.; Yanchene, R. A.; Terent'ev, P. B.; Stumbryavichute, Z. A.; Bulakhov, G. A. Chem. Heterocycl. Compd. 1994, 30, 88. [Khim. Geterotsikl. Soedin. 1994, 99.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01164741

Downloads

Published

1994-01-25

Issue

No. 1 (1994)

Section

Original Papers